Worldwide, cardiac arrest among hospitalized people of all ages is a high-risk event associated with significant morbidity and mortality. To address a growing need to improve the quality standards for responding to an in-hospital cardiac arrest (IHCA), the International Liaison Committee on Resuscitation (ILCOR) has identified 10 steps that can lead to better patient outcomes and survival. These steps can be embedded in a system of care that includes plans and preparations for IHCA, prevention of IHCA when avoidable, implementation of effective resuscitation education and training, the delivery of high-quality guidelines-based resuscitation care, and ongoing evaluation and adjustments for improvements within a culture of person-centered care.