Pediatric Resuscitation Quality Collaborative
Research Studies
*as of November 2025
OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)
PI: Robert Sutton, MD (Children’s Hospital of Philadelphia)
The goal of the study is to determine the effectiveness of a pediatric CPR ventilation training bundle to improve outcomes after pediatric in-hospital cardiac arrest in a prospective multicenter “adaptive,” parallel, hybrid stepped-wedge, cluster randomized interventional trial.
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest (PEDICA)
PI: Ryan Morgan, MD (Children’s Hospital of Philadelphia)
The goal of the study is to better delineate the physiologic effects of epinephrine during cardiopulmonary resuscitation and how that information can inform more targeted epinephrine dosing strategies to improve outcomes.
Situation Awareness Incorporating MUltidisciplinary Teams Reduce Arrest In the PICU (SAMURAI)
PI: Maya Dewan, MD MPH (Cincinnati Children’s Hospital Medical Center)
Primary focus is on unit-based interventions to reduce the incidence of IHCA in PICUs using quality improvement methodology. To improve success of future intervention, this study collects additional information on attitudes, behaviors, and intervention usability, fidelity, and acceptability of the intervention by a collective group of stakeholders.